Vastarel MR (Trimetazidine
20 mg Modified Release) abridged prescribing information
Trimetazidine (Generic Vastarel®) is used in the treatment of
ischaemic heart disease (angina pectoris, sequelae of infarction).
Indication
Long-term treatment of angina pectoris.
Other applications
In France and possibly other countries,
Trimetazidine is prescribed for the treatment of tinnitus, vertigo or
dizziness, and for the treatment of visual problems thought to have a
circulatory basis. The
Trimetazidine dosage and administration in these cases is identical as
for cardiac applications (see below).
Pharmacodynamic properties
By preserving the energy metabolism in cells exposed to hypoxia or
ischemia,
Trimetazidine prevents a decrease in intracellular ATP levels, thereby
ensuring the proper functioning of ionic pumps and transmembranous
sodium-potassium flow whilst maintaining cellular homeostasis.
In man: controlled studies in angina patients have shown that
Trimetazidine increases coronary flow reserve, thereby delaying the
onset of ischemia associated with exercise, limits rapid swings in blood
pressure without any significant variations in heart rate, significantly
decreases the frequency of angina attacks, and leads to a significant
decrease in the use of nitrates.
Trimetazidine Precautions
Pregnancy: Studies in animals have not demonstrated a teratogenic effect.
However, in the absence of clinical data and for safety reasons,
prescription should be avoided during pregnancy, don't stop taking
vastarel and generic without consultant .
Breastfeeding: In the absence of data, breastfeeding is not recommended
during treatment.
Trimetazidine
Side effects:
Rare cases of gastrointestinal disorders.
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