Rosiglitazone is an anti-diabetic drug from the thiazolidinedione
class. It is being marketed as Avandia® by the pharmaceutical company
GlaxoSmithKline, both as a standalone preparation and in combination with
metformin (Avandamet®). Another combination drug approved by the FDA is
Avandaryl® (with glimepiride).
Like other thiazolidinediones, its mechanism of action is by activation of
the intracellular receptor class of the peroxisome proliferator-activated
receptors (PPARs), specifically PPAR.
Rosiglitazone is a pure ligand of PPAR, and has no PPAR-binding
action. Apart from its effect on insulin resistance, it appears to have an
anti-inflammatory effect: nuclear factor kappa-B levels fall and
inhibitor levels increase in patients on
Rosiglitazone (Mohanty et al).
Rosiglitazone maleate Description
Rosiglitazone (ROS-e-glit-a-zone) is used to treat a certain type of
diabetes mellitus (sugar diabetes) called type 2 diabetes. It may be used
alone or with another type of diabetes medicine, such as metformin,
insulin, a sulfonylurea, or sulfonylurea plus metformin.
Rosiglitazone Dosing
The dose of
Rosiglitazone will be different for different patients. Follow your
doctor's orders or the directions on the label. If your dose is different,
do not change it unless your doctor tells you to do so.
Where can i order Rosiglitazone ?
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Rosiglitazone works great for glucose control when used in combination
with Glucophage. Tyler.
Glucose levels have dropped and i have more energy. Ava.
I have more energy, and my blood sugar dropped quickly. David.
I called a pharmacist and took only 4 mg of Rosiglitazone along with 5 mg.
of glipizide...BP going down, HR dropping: in ONE DAY! This is touch and
go. I think it is a very good drug...I was in sugar range of 360 in
December...it was 101 on Feb. 23 and 147 Feb. 26. Anthony.