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Generic Name: Nateglinide
Brand Name: Starlix
Drug Class And Mechanism: Nateglinide is an oral drug used to lower blood
sugar (glucose) levels in type 2 diabetes. It is in a class of drugs
called meglitinides which also includes repaglinide (Prandin).
Approximately 90% of patients with diabetes have type 2 diabetes. Type 2
diabetes usually occurs in adults and is associated with obesity and a
strong family history of diabetes. Insulin is an important hormone that
controls the blood level of glucose. Type 2 diabetics have an inability to
control blood glucose levels. This is caused by reduced secretion of
insulin from the pancreas after meals and resistance of the body's cells
to the effect of insulin which is to stimulate the cells to remove glucose
from the blood. This leads to high levels of blood glucose. Nateglinide
stimulates cells in the pancreas to produce insulin in a manner similar to
the class of drugs called sulfonylureas, e.g., glyburide (Diabeta, Glynase
and Micronase) ( starlix insulin )which also are used in type 2 diabetes.
However, Nateglinide appears to have a faster onset and a shorter duration
of action than sulfonylureas. The benefit of this faster, shorter effect
may be to prevent the rapid, transient rise in blood glucose that occurs
in diabetics immediately following a meal. Nateglinide was approved by the
FDA in December, 2000.
Storage: Nateglinide should be stored at room temperature,
15-30°C(59-86°F) in an air-tight container.
Prescribed For: Nateglinide is used to control blood glucose levels in
type 2 diabetes. It may be used with diet and exercise when diet and
exercise alone are not successful in controlling blood glucose. It also
may be used with metformin, another drug that is used for controlling
blood glucose in type 2 diabetes. Nateglinide is not recommended if blood
glucose levels have not been controlled by a sulfonylurea since
Nateglinide and sulfonylureas have a similar mechanism of action.
Therefore, if sulfonylureas are ineffective, it is likely that Nateglinide
also will be ineffective.
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